1. Shop
  2. Products
  3. L-5-MTHF

L-5-MTHF provides 1 mg (1,700 mcg DFE) of natural, biologically active form of folate, which is essential for cell division and growth, and also works to balance the homocysteine pathway.


This formula provides folate in the bioidentical, bioactive form, 5-methyltetrahydrofolate. In L-5-MTHF, the “L” signifies that it is an all-natural [6S] isomer, and this is the active circulating form of folate found in the body and one of the several forms found in food.

In nature, this is found only as this [6S] isomer, which is why Designs for Health uses L-5-MTHF, the natural isomer, rather than the mixed (or racemic) form. This product uses the patented folate derivative, Quatrefolic®.

This innovative form of folate has demonstrated high bioavailability, solubility, and long-lasting stability. Quatrefolic® L-5-MTHF has been shown to help increase blood folate levels much better than folic acid.

120 vegetarian capsules.

Gluten free, dairy free, soy free, vegetarian, non-gmo.